Similarly, parents of children with SCID embark on a complex journey marked by a variety of informational and emotional support needs. Even after a diagnosis is received, parents of children with rare disorders live with other uncertainties related to the long-term outcomes for their child and the impact on their family. Although newborn screening alleviates the search for a diagnosis, it is not unusual for parents to experience increased anxiety and uncertainty as they wait on confirmatory testing results. Parents of children with a rare disorder often experience a diagnostic odyssey which is marked by high levels of stress and uncertainty. Newborn screening has improved the clinical prognosis for children with SCID, with 92% of infants surviving after treatment. Given that SCID is considered a medical emergency and treatments have been shown to significantly reduce morbidity and mortality, all states now screen newborns at birth for the condition. Individuals with SCID are at risk for life-threating illness unless diagnosed and treated early, typically with a hematopoietic stem cell transplant or, with some variants, gene therapy. Severe combined immunodeficiency (SCID) is a group of rare, genetic conditions characterized by a decreased amount or absence of T-cells, which results in a lack of a functioning immune system. The results speak to the need for healthcare providers to prepare parents for the SCID journey by providing resources to help manage and cope with uncertainty. Parents expressed a variety of negative emotional reactions to uncertainty, from anxiety, worry, and fear, to doubt, guilt, or grief, and even anger, frustration, and depression. Some uncertainties were more prominent at certain points of the journey whereas others spanned multiple stages. We found that uncertainties in the SCID journey were chronic and multifaceted. Using deductive and inductive content analysis, we describe the type of uncertainty experienced across each stage of the SCID journey. Each interview was recorded, transcribed, and coded. We conducted semi-structured interviews with 26 parents to discuss the types of uncertainty experienced, including scientific, practical, personal, and existential. This paper explored the types of uncertainties experienced by parents of a child with SCID diagnosed through newborn screening. Even after early identification through newborn screening, parents of children with SCID embark on a complex journey marked by a variety of informational and emotional support needs. Control of gastricacid secretion in health and disease.Individuals with severe combined immunodeficiency (SCID), a group of rare, genetic conditions, are at risk for life-threatening illnesses unless diagnosed and treated early. Effectof hypochlorhydria due to omeprazole treatment or atrophic gastritis onprotein-bound vitamin B12 absorption. (2016).Nutritional interventions for gastroesophageal reflux, irritable bowelsyndrome, and hypochlorhydria: A case report. Role of Helicobacterpylori infection on nutrition and metabolism. Gastric balance: Heartburn not always caused by excessacid. Theevolution of stomach acidity and its relevance to the human microbiome. The role of HCL ingastric function and health. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Surgeries of the stomach, such as gastric bypass surgery, can reduce production of stomach acid. If left untreated, it can result in decreased stomach acid. Pylori is a common cause of gastric ulcers. If you take these medications and are concerned that you have symptoms of low stomach acid, speak with your doctor before making changes to your medications. Taking antacids or medications prescribed to treat ulcers and acid reflux, such as PPIs, for a long period of time may also lead to hypochlorhydria. These deficiencies may be caused by inadequate dietary intake or by nutrient loss from stress, smoking, or alcohol consumption. Deficiency of zinc or B vitamins may also lead to low stomach acid. Chronic stress may decrease production of stomach acid. People over the age of 65 years are most likely to have low levels of hydrochloric acid. Hypochlorhydria is much more common as you get older. Some of the most common causes for low stomach acid include:
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |